Practicable diagnostics of Sj ögren's syndrome in interstitial lung disease-A discussion article

Z Rheumatol. 2023 Mar 22. doi: 10.1007/s00393-023-01344-3. Online ahead of print.ABSTRACTSjögren's syndrome (SjS) is a possible autoimmune cause of interstitial lung disease. The diagnostic pathway for SjS, however, is largely undefined in comparison to other systemic autoimmune diseases. Subjective sicca symptoms, anti-SS-A/Ro antibodies and even ANA as screening tests all have relevant limitations in sensitivity and/or specificity. Against this background, in an interdisciplinary discussion we have developed a consensus for the clarification of SjS, which is presented here for broader discussion. In addition to ANA and anti-SS-A/Ro antibodies, antibodies against alpha-fodrin should be included. Objective measures of dryness, such a Schirmer and Saxon tests are important, as is a salivary gland biopsy in the absence of typical autoantibodies.PMID:36949162 | DOI:10.1007/s00393-023-01344-3
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Source Type: research