Cancers, Vol. 15, Pages 1983: Venetoclax for Acute Myeloid Leukemia in Pediatric Patients: A Texas Medical Center Experience
Cancers, Vol. 15, Pages 1983: Venetoclax for Acute Myeloid Leukemia in Pediatric Patients: A Texas Medical Center Experience
Cancers doi: 10.3390/cancers15071983
Authors:
Adriana Trabal
Amber Gibson
Jiasen He
David McCall
Michael Roth
Cesar Nuñez
Miriam Garcia
Meredith Buzbee
Laurie Toepfer
Aram Bidikian
Naval Daver
Tapan Kadia
Nicholas J. Short
Ghayas C. Issa
Farhad Ravandi
Courtney D. DiNardo
Guillermo Montalban Bravo
Sofia Garces
Andrea Marcogliese
Hana Paek
Zoann Dreyer
Julienne Brackett
Michele Redell
Joanna Yi
Guillermo Garcia-Manero
Marina Konopleva
Alexandra Stevens
Branko Cuglievan
The BCL-2 inhibitor venetoclax improves survival for adult patients with acute myeloid leukemia (AML) in combination with lower-intensity therapies, but its benefit in pediatric patients with AML remains unclear. We retrospectively reviewed two Texas Medical Center institutions’ experience with venetoclax in 43 pediatric patients with AML; median age 17 years (range, 0.6–21). This population was highly refractory; 44% of patients (n = 19) had ≥3 prior lines of therapy, 37% (n = 16) had received a prior bone marrow transplant, and 81% (n = 35) had unfavorable genetics (KMT2A (n = 17), WT1 (n = 13), FLT3-ITD (n = 10), monosomy 7 (n = 5), TP53 (n = 3), Inv(3) (n = 3), IDH1/2 (n = 2), monosomy 5 (n = 1), NUP98 (n = 1) and ASXL1 (n = 1). The majority (86%) received venetoclax with a hypomethyla...
Source: Cancers - Category: Cancer & Oncology Authors: Adriana Trabal Amber Gibson Jiasen He David McCall Michael Roth Cesar Nu ñez Miriam Garcia Meredith Buzbee Laurie Toepfer Aram Bidikian Naval Daver Tapan Kadia Nicholas J. Short Ghayas C. Issa Farhad Ravandi Courtney D. DiNardo Guillermo Montalban Bravo Tags: Article Source Type: research
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