Viruses, Vol. 15, Pages 849: Prevention of the Vertical Transmission of HIV; A Recap of the Journey so Far

This study reported a 67.5% reduction in perinatal HIV transmission with prophylactic antenatal, intrapartum, and postnatal zidovudine. Numerous studies since then have provided compelling evidence to further optimize interventions, such that annual transmission rates of 0% are now reported by many health departments in the US and elimination has been validated in several countries around the world. Despite this success, the elimination of HIV’s vertical transmission on the global scale remains a work in progress, limited by socioeconomic factors such as the prohibitive cost of antiretrovirals. Here, we review some of the key trials underpinning the development of guidelines in the US as well as globally, and discuss the evidence through a historic lens.

Source: Viruses - March 26, 2023 Category: Virology Authors: Maria Camila Cardenas Sheila Farnan Benjamin L. Hamel Maria Camila Mejia Plazas Elise Sintim-Aboagye Dawn R. Littlefield Supriya Behl Sohan Punia Elizabeth Ann L Enninga Erica Johnson Zelalem Temesgen Regan Theiler Clive M. Gray Rana Chakraborty Tags: Review Source Type: research