Discovery and Classification of Fusion Transcripts in Prostate Cancer and Normal Prostate Tissue.

Discovery and Classification of Fusion Transcripts in Prostate Cancer and Normal Prostate Tissue.
Am J Pathol. 2015 May 8;
Authors: Luo JH, Liu S, Zuo ZH, Chen R, Tseng GC, Yu YP
Abstract
Fusion transcript formation is one of the fundamental mechanisms that drives the development of prostate cancer. Because of the advance of high-throughput parallel sequencing, many fusion transcripts have been discovered. However, the discovery rate of fusion transcripts specific for prostate cancer is lagging behind the discoveries made on chromosome abnormalities of prostate cancer. Recent analyses suggest that many fusion transcripts are present in both benign and cancerous tissues. Some of these fusion transcripts likely represent important components of normal gene expression in cells. It is necessary to identify the criteria and features of fusion transcripts that are specific for cancer. In this review, we discuss optimization of RNA sequencing depth for fusion transcript discovery and the characteristics of fusion transcripts in normal prostate tissues and prostate cancer. We also propose a new classification of cancer-specific fusion transcripts on the basis of their tail gene fusion protein product and the roles that these fusions may play in cancer development.
PMID: 25963990 [PubMed - as supplied by publisher]

Source: The American Journal of Pathology - May 8, 2015 Category: Pathology Authors: Luo JH, Liu S, Zuo ZH, Chen R, Tseng GC, Yu YP Tags: Am J Pathol Source Type: research