The IL-33:ST2 axis is unlikely to play a central fibrogenic role in idiopathic pulmonary fibrosis

CONCLUSIONS: Together these findings suggest the IL-33:ST2 axis does not play a central fibrogenic role in the lungs with therapeutic blockade of this pathway unlikely to surpass the current standard of care for IPF.PMID:36949463 | DOI:10.1186/s12931-023-02334-4

Source: Respiratory Care - March 23, 2023 Category: Respiratory Medicine Authors: Katherine E Stephenson Joanne Porte Aoife Kelly William A Wallace Catherine E Huntington Catherine L Overed-Sayer E Suzanne Cohen R Gisli Jenkins Alison E John Source Type: research