Inhibition of type 5 phosphodiesterase counteracts {beta}2-adrenergic signalling in beating cardiomyocytes

Conclusion
These data identify a new effect of PDE5 inhibitors on the modulation of cardiomyocyte response to adrenergic stimulation via PDE5–PDE2-mediated cross-talk.

Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Isidori, A. M., Cornacchione, M., Barbagallo, F., Di Grazia, A., Barrios, F., Fassina, L., Monaco, L., Giannetta, E., Gianfrilli, D., Garofalo, S., Zhang, X., Chen, X., Xiang, Y. K., Lenzi, A., Pellegrini, M., Naro, F. Tags: Cardiac biology and remodelling Source Type: research