Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT)

This study provides a proof-of-concept for robust and fast screening of drug sensitivities of PDCs in 3D-DSRT, which is important not only for drug discovery but also for personalized ex vivo drug testing in functional precision medicine studies. These findings suggest that comparing results of 2D- and 3D-DSRT is essential for understanding drug mechanisms and for selecting the most effective treatment for the patient.PMID:36934951 | DOI:10.1016/j.slasd.2023.03.002

Source: Cancer Control - March 19, 2023 Category: Cancer & Oncology Authors: Michaela Feodoroff Piia Mikkonen Laura Turunen Antti Hassinen Lauri Paasonen Lassi Paavolainen Swapnil Potdar Astrid Murum ägi Olli Kallioniemi Vilja Pieti äinen Source Type: research