Stigmastane-type steroid saponins from the leaves of < em > Vernonia amygdalina < /em > and their < em > α < /em > -glucosidase and xanthine oxidase inhibitory activities

Nat Prod Res. 2023 Mar 16:1-6. doi: 10.1080/14786419.2023.2188589. Online ahead of print.ABSTRACTTwo new vernonioside K (1) and vernonioside L (2) and four known Δ7,9(11) stigmastane-type steroidal saponins-vernonioside B2 (3), vernoniacum B (4), vernonioside B1 (5), and vernoamyoside A (6)-were isolated from the leaves of Vernonia amygdalina. Their structures were determined by comprehensive spectroscopic analysis with one-dimensional nuclear magnetic resonance, two-dimensional nuclear magnetic resonance, and high-resolution mass spectrometry. All isolated compounds (1-6) were evaluated to determine their inhibitory effects on α-glucosidase and xanthine oxidase. Among them, two new compounds 1 and 2 showed significant inhibition of α-glucosidase with IC50 values of 78.56 ± 7.28 and 14.74 ± 1.57 (μM), respectively, comparable with acarbose as a positive control (127.53 ± 1.73 μM); none of these compounds inhibited xanthine oxidase activity. Compounds 1 and 2 are promising candidates for the development of antidiabetic agents from natural sources.PMID:36924396 | DOI:10.1080/14786419.2023.2188589

Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: PCong Pham Van Hieu Ngo Van Minh Bui Quang Nam Duong Thanh Dan Nguyen Van Tuan Do Thanh Ngoc Tran Minh Hien Nguyen Thi Thu Trung Nguyen Quang Thi Thao Do Loan Pham Thanh Hien Do Thi Thu Anh Hoang Le Tuan Source Type: research