Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery

In conclusion, our findings strongly support the concept of grouping PAs into potency classes and help to pave the way for a broader acceptance of relative potency factors in risk assessment.PMID:36928417 | DOI:10.1007/s00204-023-03482-8

Source: Archives of Toxicology - March 17, 2023 Category: Toxicology Authors: Manuel Haas Karina Wirachowski Lea Thibol Jan-Heiner K üpper Dieter Schrenk J örg Fahrer Source Type: research