4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes

CONCLUSIONS: These results provided the first evidence to date that OI can prevent the progression of glycemic deterioration, excessive inflammation, and beta cell dysfunction predominantly mediated by restricting macrophage M1 polarization in mouse models of type 1 diabetes.PMID:36918798 | PMC:PMC10015936 | DOI:10.1186/s10020-023-00626-5

Source: Molecular Medicine - March 15, 2023 Category: Molecular Biology Authors: Sunyue He Yuchen Zhao Guoxing Wang Qiaofang Ke Nan Wu Lusi Lu Jiahua Wu Shuiya Sun Weihua Jin Wenjing Zhang Jiaqiang Zhou Source Type: research