Talarostatin, a vermistatin derivative from the soil-derived fungus < em > Talaromyces thailandensis < /em > PSU-SPSF059

Nat Prod Res. 2023 Mar 15:1-8. doi: 10.1080/14786419.2023.2188209. Online ahead of print.ABSTRACTThe soil-derived fungus Talaromyces thailandensis PSU-SPSF059 produced one new vermistatin derivative, talarostatin, and seven known compounds including two vermistatins, two chrodrimanins, two diphenyl ethers and one penicillide derivative. Extensive spectroscopic analysis was performed to identify their structures. The absolute configuration of talarostatin was determined by comparing the experimental and calculated electronic circular dichroism data. The antimicrobial and cytotoxic activities of the isolated secondary metabolites were also evaluated.PMID:36919631 | DOI:10.1080/14786419.2023.2188209

Source: Natural Product Research - March 15, 2023 Category: Biochemistry Authors: Baiq Nila Sari Ningsih Vatcharin Rukachaisirikul Souwalak Phongpaichit Chatchai Muanprasat Sita Preedanon Jariya Sakayaroj Ratchadaree Intayot Siriporn Jungsuttiwong Source Type: research