Chemical constituents from < em > Trillium camschatcense < /em >

Nat Prod Res. 2023 Mar 16:1-10. doi: 10.1080/14786419.2023.2188211. Online ahead of print.ABSTRACTTwo undescribed polyacetylated 18-norspirostanol saponins, trilliumosides J (1) and 21-deoxyepitrillenoside C (2), a novel resveratrol aneuploid, 3a,3b-dimethoxyhopeachinol B (3) along with four known steroidal saponins (4-7), were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium camschatcense. The structures of isolated compounds were elucidated by spectroscopic analysis and chemical degradation. Compounds 1,3 and 4 had potential cytotoxic activity against MCF-7, with IC50 values 86.38 ± 2.59 μM, 56.20 ± 1.57 μM and 45.70 ± 0.63 μM.PMID:36924397 | DOI:10.1080/14786419.2023.2188211

Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: Jianwei Xie Kunjun Wang Xiaoxu Gao Anhua Wang Gaosheng Hu Ting Yan Jingming Jia Source Type: research