Moffitt researchers say androgen deprivation therapy may lead to cognitive impairment

(H. Lee Moffitt Cancer Center &Research Institute) Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. After chemotherapy treatment it is commonly called 'chemo brain.' Signs of cognitive impairment include forgetfulness, inability to concentrate, problems recalling information, trouble multi-tasking and becoming slower at processing information. The number of people who experience cognitive problems following cancer therapy is broad, with an estimate range of 15 to 70 percent.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Before she was Foundation Medicine‘s (NSDQ:FMI) chief business executive, Melanie Nallicheri was as an advisor to an ongoing project at the Cleveland Clinic, where she was witness to the power of personalized cancer treatment. Her team was caring for a patient with glioblastoma – an extremely aggressive form of brain cancer with a median survival time of 15 months. “The patient had resection and radiation and the question was: so now what?” she told Drug Delivery Business News. They turned to the patient’s molecular profile in search of answers, scouring over millions of pieces of data. T...
Source: Mass Device - Category: Medical Devices Authors: Tags: Diagnostics Food & Drug Administration (FDA) Pharmaceuticals Regulatory/Compliance Wall Street Beat Foundation Medicine Inc. Merck Source Type: news
By Michelle Catenacci, M.DCHICAGO, Jun 18 2018 (IPS)Fertility health is an incredibly personal – and often vulnerable – topic. Fertility, infertility, and fertility preservation have gained increased public interest over the past few years. Infertility is formally defined as the inability to achieve pregnancy after one year of unprotected intercourse. The Centers for Disease Control and Prevention (CDC) reports that approximately 12% of women aged 15 to 44 in the United States have difficulty getting pregnant or carrying a pregnancy to term. Even though a significant proportion of the population suffers from th...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Education Featured Gender Global Headlines Health Population Poverty & SDGs TerraViva United Nations Source Type: news
Dysphagia is a swallowing impairment that can occur after someone has a stroke or any type of brain injury. Dysphagia is also a concern with Parkinson’s disease, multiple sclerosis (MS), oral cancer, and many other injuries and diseases. However, according to the National Institutes of Health (NIH), dysphagia is also a growing concern in Alzheimer’s Disease (AD). The NIH says that dysphagia “frequently leads to aspiration pneumonia, a common cause of death in this population, particularly in the later stage of AD.” Read full article on HealthCentral and get free downloads, and free re...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Jalil Ur Rehman, Muhammad Isa, Nisar Ahmad, Gulfam Nasar, H M. Noor Ul Huda Khan Asghar, Zaheer Abbas Gilani, James C. L. Chow, Muhammad Afzal, Geoffrey S IbbottJournal of Medical Physics 2018 43(2):129-135This analysis estimated secondary cancer risks after volumetric modulated arc therapy (VMAT) and compared those risks to the risks associated with other modalities of head-and-neck (H&N) radiotherapy. Images of H&N anthropomorphic phantom were acquired with a computed tomography scanner and exported via digital imaging and communications in medicine (DICOM) standards to a treatment planning system. Treatment plan...
Source: Journal of Medical Physics - Category: Physics Authors: Source Type: research
I’ve thought a great deal about what to say, if anything, about the two suicides recently of two people who were not merely celebrities in the TMZ sense, but people who represented creativity — perhaps in a way that seemed tangible to the rest of us — and seem to have become celebrities almost by happenstance. Suicide is not an unfamiliar or difficult topic for me. After all, I am someone who has spent the better part of the last nine years addressing someone’s struggle with suicide, day in and day out. As a physician, I’ve been exposed many times to untimely death — whether intentional ...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Psychiatry Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Clinical Significance of Human Papillomavirus Type 16 for Breast Cancer &Adenocarcinomas of Various Internal Organs and Alzheimer's Brain with Increased β-amyloid (1-42); Combined Use of Optimal Doses of Vitamin D3 and Taurine 3 times/day Has Significant Beneficial Effects of Anti-Cancer, Anti-Ischemic Heart, and Memory &Other Brain Problems By Significant Urinary Excretion of Viruses, Bacteria, and Toxic Metals &Substances. Acupunct Electrother Res. 2016;41(2):127-134 Authors: Omura Y Abstract Human Papillomavirus type 16 (HPV-16) has a significant role in various cancers and Alzheime...
Source: Acupuncture and Electro-Therapeutics Research - Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research
Authors: Yamamoto Y, Sasaki N, Kumagai K, Takeuchi S, Toyooka T, Otani N, Wada K, Narita Y, Ichimura K, Namba H, Mori K, Tomiyama A Abstract Glioblastoma (GBM) still carries a poor prognosis due to the refractoriness against antitumor drugs. Temozolomide (TMZ), one of the few standard therapy drugs against GBM worldwide, has only limited effect due to acquired TMZ resistance of GBM. Therefore, development of novel therapeutic methods to overcome the TMZ resistance of GBM is urgent. The brain is the most cholesterol-rich organ in the human body, so modulation of cholesterol in tumor cells originating from the brain ...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
Authors: Zhang Y, Xia Q, Lin J Abstract Glioblastoma (GBM) is a common malignant tumour in the human brain, but its molecular mechanisms have not been systematically evaluated. The aim of this study was to identify potential key oncogenes associated with the progression of GBM and to elucidate their mechanisms. The gene expression profile of GSE50161, selected from the Gene Expression Omnibus database, was analysed to find cancer‑associated genes and gene functions in GBM. In total, 486 differentially expressed genes, including 128 upregulated genes, were identified. The function and pathway enrichment of these g...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Conclusion: While no single variant was associated with brain metastasis, this study describes a potential gene panel for the identification of patients at risk and implicates PI3K/AKT signaling as a therapeutic target. PMID: 29899834 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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