Sinoflavonoids NJ and NK, anti-inflammatory prenylated flavonoids from the fruits of < em > Podophyllum hexandrum < /em > Royle

Nat Prod Res. 2023 Mar 13:1-5. doi: 10.1080/14786419.2023.2188590. Online ahead of print.ABSTRACTTwo new prenylated flavonoids named sinoflavonoids NJ and NK (1-2), along with ten known compounds were isolated from the fruits of Podophyllum hexandrum Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ (1) with an unusual 5,11-dioxabenzo[b]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested with LPS-induced RAW 264.7 mouse macrophages model for their anti-inflammatory activity. Sinoflavonoid NJ (1) showed the most potent inhibition on nitric oxide production with IC50 value as 0.06 μM.PMID:36915053 | DOI:10.1080/14786419.2023.2188590
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research