Clinical and genomic characterization of Chinese patients with functional high-risk multiple myeloma: A real-world validation study

ConclusionThe FHR found in the SR NDMM patient group has unique clinical features, including being male, with EMD and CPC, and genetic characteristics of mutations affecting oxidative stress, chromosome segregation, and hypoxia tolerance. In contrast to previous reports, our data suggested that patients with P53 mono-allelic inactivation should be classified in the GHR group rather than the FHR group.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research