Wnt/ β-catenin signaling inhibitors

We describe the structure, mechanisms, and functions of these small molecules during cancer treatment in preclinical and clinical trials. We also review several Wnt/β-catenin inhibitors reported to exhibit anti-angiogenic effects. Finally, we explain various challenges in the targeting of the Wnt/β-catenin signaling pathway in human cancer treatment and suggest potential therapeutic approaches to human cancer.PMID:36872364 | DOI:10.2174/1568026623666230303101810
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research