Cancers, Vol. 15, Pages 1660: Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone: The PROSPER Study Rationale and Design
Cancers, Vol. 15, Pages 1660: Pragmatic, Prospective Comparative Effectiveness Trial of Carbon Ion Therapy, Surgery, and Proton Therapy for the Management of Pelvic Sarcomas (Soft Tissue/Bone) Involving the Bone: The PROSPER Study Rationale and Design
Cancers doi: 10.3390/cancers15061660
Authors:
Bradford S. Hoppe
Ivy A. Petersen
Benjamin K. Wilke
Todd A. DeWees
Reiko Imai
Eugen B. Hug
Maria Rosaria Fiore
Jürgen Debus
Piero Fossati
Shigeru Yamada
Ester Orlandi
Qing Zhang
Cihang Bao
Katharina Seidensaal
Byron C. May
Anna C. Harrell
Matthew T. Houdek
Laura A. Vallow
Peter S. Rose
Michael G. Haddock
Jonathan B. Ashman
Krista A. Goulding
Steven Attia
Sunil Krishnan
Anita Mahajan
Robert L. Foote
Nadia N. Laack
Sameer R. Keole
Chris J. Beltran
Eric M. Welch
Mohammed Karim
Safia K. Ahmed
Surgical treatment of pelvic sarcoma involving the bone is the standard of care but is associated with several sequelae and reduced functional quality of life (QOL). Treatment with photon and proton radiotherapy is associated with relapse. Carbon ion radiotherapy (CIRT) may reduce both relapse rates and treatment sequelae. The PROSPER study is a tricontinental, nonrandomized, prospective, three-arm, pragmatic trial evaluating treatments of pelvic sarcoma involving the bone. Patients aged at least 15 years are eligible for inclusion. Participants must have an Eastern Cooperative Oncology Group Performance Status score of two or le...
Source: Cancers - Category: Cancer & Oncology Authors: Bradford S. Hoppe Ivy A. Petersen Benjamin K. Wilke Todd A. DeWees Reiko Imai Eugen B. Hug Maria Rosaria Fiore J ürgen Debus Piero Fossati Shigeru Yamada Ester Orlandi Qing Zhang Cihang Bao Katharina Seidensaal Byron C. May Anna C. Harrell Matthew T. Hou Tags: Study Protocol Source Type: research
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