Repurposed anti-cholesterol drug could improve treatment-resistant anemias
Diamond Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome, is usually diagnosed during childhood and is typically treated with glucocorticoids that cause a host of unwanted, often dangerous side effects. Using a mouse model, a research team has now determined that combining the cholesterol-lowering drug fenofibrate with glucocorticoids could allow for dramatically lower steroid doses in the treatment of DBA and other erythropoietin-resistant anemias. These promising results are the foundation for a clinical trial that will begin soon.
Conclusions: Lipid metabolic process was critical in both macrophage aging and response to cholesterol thus was regarded to be associated with the occurrence and progression of AMD. Moreover, miR-714-FDFT1 may modulate cholesterol homeostasis in aged macrophages and have the potential to be a novel therapeutic target for AMD. PMID: 32626771 [PubMed - in process]
In conclusion, patients with acquired PRCA may have clonal gene mutations. The patients withBCOR andBCORL1 mutations may suggest a better response to IST compared with those with other mutations.
In conclusion, the present study indicated that statin use might be a protective factor for MM incidence. However, the relationship between statin use a nd MM risk requires repeated and large prospective studies to be verified.
AbstractHematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) have been widely accepted as the standard first-line treatments for severe aplastic anemia (SAA). However, most of the patients with SAA had a slim chance to access these strategies in developing countries. Here, we reported 10-year results in a cohort of 232 patients with SAA who received a novel IST of CsA, levamisole, and danazol (CsA&LMS-based regimen). The cumulative incidence of response was 52.1% at 6 months, 66.4% at 12 months, and 77.1% at 24 months. Th...
Publication date: Available online 6 July 2020Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Neha R. Patil, Erica S. Herc, Marian Girgis
Conditions: Hematocrit Anemia; Acidosis Intervention: Procedure: Umbilical cord clamping at birth. Sponsor: Policlinico Abano Terme Not yet recruiting
CONCLUSIONS: PCSK-9 is independently associated with triglycerides, Lp(a) levels, and HOMA-IR, but not LDL-C, in a relatively large general population sample. PMID: 32624555 [PubMed - as supplied by publisher]
Older adults can reduce their risk for a fatal heart attack or stroke by 20 percent by taking a statin. Those over age 75 who were newly prescribed cholesterol-lowering drugs were 25 percent less likely to die.
TUESDAY, July 7, 2020 -- Older adults with healthy hearts probably would benefit from taking a cholesterol-lowering statin, a new study contends. People 75 and older who were free of heart disease and prescribed a statin wound up with a 25% lower...
Publication date: Available online 3 July 2020Source: Fish &Shellfish ImmunologyAuthor(s): Francisca Samsing, John Hoad, Peter Mohr, Megan Dearnley, James W. Wynne