Repurposed anti-cholesterol drug could improve treatment-resistant anemias

Diamond Blackfan anemia (DBA), a rare inherited bone marrow failure syndrome, is usually diagnosed during childhood and is typically treated with glucocorticoids that cause a host of unwanted, often dangerous side effects. Using a mouse model, a research team has now determined that combining the cholesterol-lowering drug fenofibrate with glucocorticoids could allow for dramatically lower steroid doses in the treatment of DBA and other erythropoietin-resistant anemias. These promising results are the foundation for a clinical trial that will begin soon.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Conclusions: Lipid metabolic process was critical in both macrophage aging and response to cholesterol thus was regarded to be associated with the occurrence and progression of AMD. Moreover, miR-714-FDFT1 may modulate cholesterol homeostasis in aged macrophages and have the potential to be a novel therapeutic target for AMD. PMID: 32626771 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
In conclusion, patients with acquired PRCA may have clonal gene mutations. The patients withBCOR andBCORL1 mutations may suggest a better response to IST compared with those with other mutations.
Source: Annals of Hematology - Category: Hematology Source Type: research
In conclusion, the present study indicated that statin use might be a protective factor for MM incidence. However, the relationship between statin use a nd MM risk requires repeated and large prospective studies to be verified.
Source: Annals of Hematology - Category: Hematology Source Type: research
AbstractHematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) have been widely accepted as the standard first-line treatments for severe aplastic anemia (SAA). However, most of the patients with SAA had a slim chance to access these strategies in developing countries. Here, we reported 10-year results in a cohort of 232 patients with SAA who received a novel IST of CsA, levamisole, and danazol (CsA&LMS-based regimen). The cumulative incidence of response was 52.1% at 6  months, 66.4% at 12 months, and 77.1% at 24 months. Th...
Source: Annals of Hematology - Category: Hematology Source Type: research
Publication date: Available online 6 July 2020Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Neha R. Patil, Erica S. Herc, Marian Girgis
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
Conditions:   Hematocrit Anemia;   Acidosis Intervention:   Procedure: Umbilical cord clamping at birth. Sponsor:   Policlinico Abano Terme Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: PCSK-9 is independently associated with triglycerides, Lp(a) levels, and HOMA-IR, but not LDL-C, in a relatively large general population sample. PMID: 32624555 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Older adults can reduce their risk for a fatal heart attack or stroke by 20 percent by taking a statin. Those over age 75 who were newly prescribed cholesterol-lowering drugs were 25 percent less likely to die.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
TUESDAY, July 7, 2020 -- Older adults with healthy hearts probably would benefit from taking a cholesterol-lowering statin, a new study contends. People 75 and older who were free of heart disease and prescribed a statin wound up with a 25% lower...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Publication date: Available online 3 July 2020Source: Fish &Shellfish ImmunologyAuthor(s): Francisca Samsing, John Hoad, Peter Mohr, Megan Dearnley, James W. Wynne
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
More News: Anemia | Bone Marrow Failure Syndrome (BMFS) | Cholesterol | Clinical Trials | Fenofibrate | Science | Tricor