BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity

CONCLUSION: Collectively, our findings provided novel mechanistic insights for understanding of the role of BMP7 in IDD of T1DM, and further highlighted BMP7 as a potential therapeutic target for preventing IDD in T1DM.PMID:36858954 | DOI:10.1186/s10020-023-00623-8

Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Xiao-Jun Yu Ying-Guang Wang Rui Lu Xin-Zhen Guo Yun-Kun Qu Shan-Xi Wang Hao-Ran Xu Hao Kang Hong-Bo You Yong Xu Source Type: research