Evaluation of thresholding methods for the quantification of [ < sup > 68 < /sup > Ga]Ga-PSMA-11 PET molecular tumor volume and their effect on survival prediction in patients with advanced prostate cancer undergoing [ < sup > 177 < /sup > Lu]Lu-PSMA-617 radioligand therapy

CONCLUSION: Thresholding methods commonly used in computer vision are promising tools for the semiautomatic quantification of whole-body PSMA-TV in [68Ga]Ga-PSMA-11-PET. The proposed algorithm-driven thresholding strategy is less arbitrary and less prone to biases than thresholding with predefined values, potentially improving the application of whole-body PSMA-TV as an imaging biomarker.PMID:36859618 | DOI:10.1007/s00259-023-06163-x

Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Moon Kim Robert Seifert Jana Fragemann David Kersting Jacob Murray Frederic Jonske Kelsey L Pomykala Jan Egger Wolfgang P Fendler Ken Herrmann Jens Kleesiek Source Type: research