< sup > 89 < /sup > Zr-immuno-PET using the anti-LAG-3 tracer [ < sup > 89 < /sup > Zr]Zr-BI 754111: demonstrating target specific binding in NSCLC and HNSCC

CONCLUSIONS: [89Zr]Zr-BI-754111 PET imaging shows favorable technical and biological characteristics for developing a potential predictive imaging biomarker for LAG-3-directed therapies.TRIAL REGISTRATION: ClinicalTrials.gov , NCT03780725. Registered 19 December 2018.PMID:36859619 | DOI:10.1007/s00259-023-06164-w

Source: Molecular Medicine - March 1, 2023 Category: Molecular Biology Authors: Iris H C Miedema Marc C Huisman Gerben J C Zwezerijnen Rolf Grempler Alejandro Perez Pitarch Andrea Thiele Raphael Hesse Mabrouk Elgadi Alexander Peltzer Danielle J Vugts Guus A M S van Dongen Tanja D de Gruijl C Willemien Menke-van der Houven van Oordt I Source Type: research