Estrogen receptor alpha and beta in health and disease
Publication date: Available online 26 April 2015 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Min Jia , Karin Dahlman-Wright , Jan-Åke Gustafsson Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update on ERα and ERβ in health and disease with focus on their role in cancer and metabolic disease and in the context of recent years’ success in providing genome wide data on ER function. Furthermore, potential clinical applications and challenges are also discussed.
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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