Correlation NKX2.2 IHC and < em > EWSR1 < /em > break-apart FISH in the diagnosis of Ewing sarcoma: Can combined NKX2.2 and CD99 immunoexpression obviate or minimize the need of FISH testing? First assessment study from Indian tertiary cancer care center

CONCLUSIONS: The presented study, which is the first from an Indian oncology center, showed NKX2.2 IHC is quite reliable in diagnosis of ES in the right clinicopathological context. With remarkable sensitivity and specificity of NKX2.2 IHC for diagnosis of ES, we propose that combined positivity of CD99 and NKX2.2 IHC can obviate or minimize the need of EWSR1 gene rearrangement molecular testing for diagnosis of ES.PMID:36656211 | DOI:10.4103/ijpm.ijpm_535_21
Source: Indian Journal of Pathology and Microbiology - Category: Pathology Authors: Source Type: research