Eplerenone – Cardiology MCQ
Advantages of eplerenone compared to spironolactone include all of the following except:
a) Lower progestational effect
b) Lower anti androgenic effect
c) Lower chance of gynecomastia
d) Lower chance of hyperkalemia
Correct answer: d) Lower chance of hyperkalemia
Eplerenone has more specific effect on aldosterone receptors rather than other steroid hormone receptors.
Anti androgenic effect is responsible for gynecomastia and progestational effect for abnormal vaginal bleeding which can be associated with the use of spironolactone.
Chances of hyperkalemia are similar with spironolactone and eplerenone.
Reference
Brown NJ. Eplerenone: cardiovascular protection. Circulation. 2003 May 20;107(19):2512-8.
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Source: Cardiophile MD - Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
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