Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico Approach

Curr Issues Mol Biol. 2022 Dec 23;45(1):92-109. doi: 10.3390/cimb45010007.ABSTRACTA sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-yl)-acetamide analogues 9(a-n) were synthesized by multistep synthesis. The newly synthesized compounds were well characterized, and their antimicrobial activities were carried out by disc diffusion and broth dilution methods. Further, all the novel series of compounds (9a-n), were tested against a variety of bacterial and fungal strains in comparison to Ketoconazole, Chloramphenicol, and Amoxicillin as standard drugs, respectively. Compounds 9a, 9e, and 9g as a lead molecule demonstrated a good inhibition against tested strains. Further, molecular docking studies have been performed for the potent compounds to check the three-dimensional geometrical view of the ligand binding to the targeted proteins.PMID:36661493 | PMC:PMC9857151 | DOI:10.3390/cimb45010007

Source: Current Issues in Molecular Biology - January 20, 2023 Category: Molecular Biology Authors: Lakshmi Ranganatha Venkataravanappa Mahima Jyothi Hussien Ahmed Khamees Ekaterina Silina Victor Stupin Raghu Ram Achar Mohammed Al-Ghorbani Shaukath Ara Khanum Source Type: research