Does PARP Inhibition Sensitize Chondrosarcoma Cell Lines to Chemotherapy or Radiotherapy? Results From a Three-dimensional Spheroid Cell Model

CONCLUSION: In our study, long-term PARP inhibition was more effective than short-term treatment, and only one of the three chondrosarcoma spheroid lines was sensitive to combined PARP inhibition and radiotherapy. These findings suggest subsequent animal studies should focus on long-term PARP inhibition, and temozolomide combined with talazoparib has a higher chance of success than combination with radiotherapy.CLINICAL RELEVANCE: Combination treatment of talazoparib and temozolomide was effective in reducing the viability of chondrosarcoma spheroids and spheroid growth, regardless of IDH mutation status, providing rationale to replicate this treatment combination in an animal chondrosarcoma model.PMID:36729612 | DOI:10.1097/CORR.0000000000002483

Source: Cell Research - February 2, 2023 Category: Cytology Authors: Ieva Palubeckait ė Sanne Venneker Brendy E W M van den Akker Inge H Briaire-de Bruijn Judith V M G Bove é Source Type: research