Genes, Vol. 14, Pages 405: The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS Update

This study provides an overview of current data regarding the genetic factors of PBC as well as post-GWAS approaches to identifying primary functional variants and effector genes in disease-susceptibility loci. Possible mechanisms of these genetic factors in the development of PBC are also discussed, focusing on four major disease pathways identified by in silico gene set analyses, namely, (1) antigen presentation by human leukocyte antigens, (2) interleukin-12-related pathways, (3) cellular responses to tumor necrosis factor, and (4) B cell activation, maturation, and differentiation pathways.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research