Comparative study of therapeutic protocols used in the treatment of infections caused by rickettsiales in dogs

Abstract Tick-borne diseases are caused by rickettsiales microorganisms of the genera Anaplasma and Ehrlichia, and often are diagnosed in dogs (Canis familiaris). Therapeutic protocols include antibiotics of different classes, mainly tetracyclines and derivatives. This comparative study contrasts two treatment protocols routinely used in veterinary medicine to treat Rickettsiosis and assesses the respective hematological changes. Dogs used for this research were divided in two groups: group 1, treated with long-acting oxytetracycline 15 mg kg−1 and group 2, treated with doxycycline 10 mg kg−1. The results showed that blood smears of both groups were negative for rickettsiales after therapy, with no morulae in peripheral blood samples. Hematology findings differed between animals before and after treatments. The most relevant data showed that the most common hematological changes before treatments were thrombocytopenia, anemia, and leukocytosis with eosinophilia. Both treatments were effective to treat dogs infected with Rickettsiales, and platelet counts increased in thrombocytopenic dogs after treatment, in both therapy protocols.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Source: Leukemia Research Reports - Category: Hematology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions Nucleoside hydrolases are vital enzymes for the replication of Leishmania, conserved phylogenetic marker of the genus and strong-specific immunogens. We demonstrated that NH36 is an excellent target for chemotherapy of visceral leishmaniasis. Searching for the most immunogenic fraction of promastigotes of Leishmania we described the FML antigen of L. (L.) donovani, that has as its main component, the NH36 Nucleoside hydrolase. We developed second–generation vaccines with the FML and the NH36 native antigens, and with the NH36 recombinant protein. In addition, we obtained a third generation vaccine based ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
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Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
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Source: Blood - Category: Hematology Authors: Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections Source Type: research
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Source: Blood - Category: Hematology Authors: Tags: 311. Disorders of Platelet Number or Function Source Type: research
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