Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS

CONCLUSION: In summary, our results provide evidence for significant molecular differences in ARDS patients from different etiologies and a potential synergy of extracellular matrix molecules, inflammation, and mitochondrial dysfunction in ARDS pathogenesis. The proteomic mortality signature should be further investigated in future studies to develop prediction models for COVID-19 patient outcomes.PMID:36703108 | DOI:10.1186/s10020-023-00609-6

Source: Molecular Medicine - January 26, 2023 Category: Molecular Biology Authors: Richa Batra Rie Uni Oleh M Akchurin Sergio Alvarez-Mulett Luis G G ómez-Escobar Edwin Patino Katherine L Hoffman Will Simmons William Whalen Kelsey Chetnik Mustafa Buyukozkan Elisa Benedetti Karsten Suhre Edward Schenck Soo Jung Cho Augustine M K Choi Fr Source Type: research