Klebsiella pneumoniae carrying multiple alleles of antigen 43-encoding gene of Escherichia coli associated with biofilm formation

AbstractA clinical strain ofKlebsiella pneumoniae typed as sequence type 307 carrying three different alleles of theflu gene encoding theEscherichia coli virulence factor antigen 43 associated with biofilm formation was detected and characterized. Theflu alleles are located in the chromosome inside putative integrative conjugative elements. The strain displays the phenotypes associated with Ag43, i.e. bi-phasic colony morphology and enhanced biofilm production. Furthermore, the strain produces low amount of capsule known to affect Ag43 function. Analysis of 1431 worldwide deposited genomes revealed that 3.7%Klebsiella pneumoniae carry one or twoflu alleles.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research