Cancers, Vol. 15, Pages 746: Mycosis Fungoides and S & eacute;zary Syndrome: Microenvironment and Cancer Progression
Cancers, Vol. 15, Pages 746: Mycosis Fungoides and Sézary Syndrome: Microenvironment and Cancer Progression
Cancers doi: 10.3390/cancers15030746
Authors:
Gabor Dobos
Ingrid Lazaridou
Adèle de Masson
Mycosis fungoides and Sézary syndrome are epidermotropic cutaneous lymphomas, and both of them are rare diseases. Mycosis fungoides is the most frequent primary cutaneous lymphoma. In about 25% of patients with mycosis fungoides, the disease may progress to higher stages. The pathogenesis and risk factors of progression in mycosis fungoides and Sézary syndrome are not yet fully understood. Previous works have investigated inter- and intrapatient tumor cell heterogeneity. Here, we overview the role of the tumor microenvironment of mycosis fungoides and Sézary syndrome by describing its key components and functions. Emphasis is put on the role of the microenvironment in promoting tumor growth or antitumor immune response, as well as possible therapeutic targets. We focus on recent advances in the field and point out treatment-related alterations of the microenvironment. Deciphering the tumor microenvironment may help to develop strategies that lead to long-term disease control and cure.
Source: Cancers - Category: Cancer & Oncology Authors: Gabor Dobos Ingrid Lazaridou Ad èle de Masson Tags: Review Source Type: research
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