Beta blockers in heart failure – Cardiology MCQ
Beta blockers shown to be useful in heart failure include all except:
a) Carvedilol
b) Metoprolol
c) Bisoprolol
d) Atenolol
Correct answer: d) Atenolol
Atenolol is a hydrophilic beta blocker while the rest are lipophilic.
Trials showing efficacy in heart failure:
Carvedilol: COMET Trial [1]
Metoprolol: MERIT-HF Trial [2]
Bisoprolol: CIBIS Trial [3]
References
Poole-Wilson PA, Swedberg K, Cleland JG, Di Lenarda A, Hanrath P, Komajda M, Lubsen J, Lutiger B, Metra M, Remme WJ, Torp-Pedersen C, Scherhag A, Skene A; Carvedilol Or Metoprolol European Trial Investigators. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet. 2003 Jul 5;362(9377):7-13.
Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet. 1999 Jun 12;353(9169):2001-7.
A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees. Circulation. 1994 Oct;90(4):1765-73.
Source: Cardiophile MD - Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
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