Predictors of response of rituximab in rheumatoid arthritis by weighted gene co-expression network analysis

ConclusionsBANK1 can be used as a potential biomarker to predict the response of RTX treatment in RA patients.Key Points• Identifying the hub genes BANK1 as a potential biomarker to predict the response of RTX treatment in RA patients and confirming it in validation data.• Using the WGCNA approach and LASSO analyses to identify the BANK1 in a data set consisting of two GEO data merged and assessing the correlations between BANK1 and immune infiltration by CIBERSORT algorithm.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research