Antiseizure Medication Withdrawal Practice Patterns: A Survey Among Members of the American Academy of Neurology and EpiCARE

Discussion
Most surveyed neurologists would consider withdrawing ASMs in seizure-free individuals. Seizure probability was the largest factor driving decisions, yet estimating seizure probabilities was the greatest challenge. Respondents on average indicated that they may withdraw ASM after a minimum seizure-free duration of 2 years, yet also on average were willing to withdraw when seizure risk decreased below 15%–30%, which is lower than most patients' postwithdrawal risk at 2-year seizure freedom and lower than the equivalent even of a first seizure of life. These findings will inform future efforts at developing decision support tools aimed at optimizing ASM withdrawal decisions.

Source: Neurology Clinical Practice - January 17, 2023 Category: Neurology Authors: Terman, S. W., Slinger, G., Rheaume, C. E., Haque, A. S., Smith, S. N., van Griethuysen, R., van Asch, C. J. J., Otte, W. M., Burke, J. F., Braun, K. P. J. Tags: All Clinical Neurology, All Epilepsy/Seizures, Antiepileptic drugs Research Article Source Type: research