Study on molecular anti-tumor mechanism of 2-thiohydantoin derivative based on molecular docking and bioinformatic analyses

CONCLUSION: The relevance of this 2-thiohydantoin derivative was demonstrated by our experimental tests, docking studies, and bioinformatics analysis, and it may be investigated as a lead molecule for anticancer medicines, notably as AKT1 and CKD2 inhibitors.PMID:36617706 | DOI:10.2174/1568026623666230106121527

Source: Current Topics in Medicinal Chemistry - January 9, 2023 Category: Chemistry Authors: Ali A A Al-Shawi Amr Ahmed El Arabey Dakhil Zughayir Mutlaq Wafa Ali Eltayb Marcello Iriti Mohnad Abdalla Source Type: research