Abstract P3-12-09: Factors influencing aromatase inhibitor induced musculoskeletal syndrome: Roles of menopause timing and osteoporosis therapy
Conclusions: The incidence of AIMSS in our review was 41%. Patients treated in the metastatic setting may have a lower rate of AIMSS. Our cohort revealed that more recent menopause did seem to be a risk factor. Baseline osteoporosis and osteoporosis treatments have a potential association to be explored. Management options included switching between AIs, temporary discontinuation, and NSAID treatment. Updated analysis will be presented.
canres;75/9_Supplement/P3-12-09/TBL1T1tbl1
Potential risk factors for the development of AIMSS CharacteristicN(-)Arthralgia N(%)(+)Arthralgia N(%)p-value
Type of AI Used Anastrozole
204
112(55.9)
92(45.1)
0.19 Letrozole
131
83(63.4)
48(36.6) Exemestane
36
23(64.9)
13(36.1) Menopause timing LMP < 5 years prior to AI start
151
79(52.3)
72(47.7)
0.055 LMP 5-10 years prior to AI start
40
23(57.5)
17(42.5) LMP > 10 years prior to AI start
155
102(65.8)
53(34.2) Type of therapy Adjuvant
348
200(57.5)
148(42.5)
0.067 Metastatic
22
17(77.3)
5(22.7) Baseline T-score by DEXA Scan Normal (T-score 0 to -1.49)
112
55(49.1)
57(50.9)
0.049 Osteopenia (T-score -1.5 to -2.49)
171
96(56.1)
75(43.9) Osteoporosis(T-score < -2.5)
40
29(72.5)
11(27.5) On active osteoporosis therapy† (-) Therapy
218
118(54.1)
100(45.9)
0.03 (+) Therapy
127
81(63.8)
41(32.3) † Bisphosphonate/denosumab; LMP=Last menstrual period, AI=Aromatase Inhibitor, DEXA=Dual-energy x-ray absorptiomotry
Citation Format: Clinton R Morgan, Zsolt Kulcsar, Jonathan D Jones, William F Rigby, Peter ...
Source: Cancer Research - Category: Cancer & Oncology Authors: Morgan, C. R., Kulcsar, Z., Jones, J. D., Rigby, W. F., Kaufman, P. A. Tags: Poster Session Abstracts Source Type: research
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