Effects of second-generation H1-antihistamine drugs on angiogenesis in < em > in  vivo < /em > chick chorioallantoic membrane model

CONCLUSIONS: Rupatadine showed anti-angiogenic effects in the chick CAM model, compared with desloratadine and cetirizine. The anti-angiogenic effect of rupatadine could be due to its platelet-activating factor (PAF) receptor inhibition. Thus, rupatadine could be a treatment agent in pathological processes in which angiogenesis is responsible. Further studies with larger series are needed to clarify this potential.PMID:36469932 | DOI:10.1080/15569527.2022.2152040
Source: Cutaneous and Ocular Toxicology - Category: Toxicology Authors: Source Type: research