Evaluation of the role of NMDA receptor function in antidepressant-like activity. A new study with citalopram and fluoxetine in the forced swim test in mice.

CONCLUSIONS: The present literature data indicate that the antidepressant-like activity of conventional antidepressants is generally affected by the NMDA receptor, although by modulation from different sites of the complex. Thus, it supports the issue of the ability of NMDA receptor antagonists to enhance the antidepressant action in human depression. PMID: 25933959 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25933959?dopt=Abstract

Source: Pharmacological Reports - May 4, 2015 Category: Drugs & Pharmacology Authors: Wolak M, Siwek A, Szewczyk B, Poleszak E, Bystrowska B, Moniczewski A, Rutkowska A, Młyniec K, Nowak G Tags: Pharmacol Rep Source Type: research