Dr Le Fanu's online health clinic, Friday 1st May 2015
Concerned about aches and pains? Worried about a medical condition? You can email your questions confidentially to Dr Le Fanu at firstname.lastname@example.org. Answers will be published in the health section of the Telegraph website every Friday. Today - more thoughts on sunshine and melanoma, ARMD, persistent cough, tinnitus and age limit for taking stains
The objective of this compound is to decrease the rate of rectal toxicity related to radiation therapy, by creating a gap between the prostate and rectum. Secondary benefits include decreased urinary complications and improved sexual quality of life. The hydrogel spacer maintains space for approximately 3 months, and is absorbed in about 6 months.
To evaluate the efficacy and clinical impact of 3 Tesla in-bore trans-rectal magnetic resonance-guided biopsy (3T MRGB) for prostate cancer (PCa) detection based on PIRADSv2 in patients with either suspected prostate cancer or under active surveillance.
We describe our experience using MRI fused CBCT guidance for prostate biopsy. There are no published reports on the use of CBCT guidance in prostate biopsies. We hypothesize this technique will have an adequate safety profile while accurately detecting prostate cancer.
Image-guided thermal ablation has become the standard of care for treating early stage liver cancer. However, a significant limitation to a successful ablation procedure is the heat-sink effect, which may lead to suboptimal thermal dose delivery. Currently, there is no reliable method for quantifying the heat-sink effect due to limited information on blood vessel flow and its associated anatomy relative to the ablation zone. The purpose of this study was to use 4D-flow MRI to map out liver flow patterns and correlate flow rates with ablation zone volumes.
To evaluate safety and effectiveness of yttrium-90 radioembolization to treat hepatic metastases in uveal melanoma patients that also received adjuvant immunotherapy.
Biphenotypic hepatocellular-cholangiocarcinoma (HCC-CC) is a rare type of primary liver cancer that carries a poor prognosis. Since most patients present at a stage too advanced for surgical resection, loco-regional liver directed therapy is often performed for palliative or downstaging purposes. The purpose of this study is to evaluate patient outcomes after Yttrium-90 radioembolization (Y90) in patients with HCC-CC.
Immunotherapy is a paradigm-shifting advance in cancer care, but the overall response rates remain low. There has been a renaissance in the concept of promoting the immune-responsiveness of the tumor immune microenvironment via intratumoral (IT) delivery of immunostimulatory agents. However, the optimal method for IT delivery of such medications that maximizes IT dispersion while minimizing perilesional leakage and systemic distribution is unknown. The purpose of this study was to characterize IT drug distribution and its influence on drug efficacy using conventional end-hole needles (EHNs) versus multi-sidehole needles (MSHN).
This study evaluates the relationship between onset of liver metastases and efficacy of LDT. It is our hypothesis that patients presenting with liver metastases soon after diagnosis of UM would have a worse prognosis regardless of LDT.
Immunoembolization (IE) is an effective treatment for uveal melanoma (UM) hepatic metastases . The purpose of this study is to determine the efficacy and safety of IE combined with systemic Ipilimumab (Ipi).
Control of uveal melanoma (UM) liver metastases is essential to prolonging overall survival (OS). At our institution, immunoembolization (IE) is considered a 1st line liver-directed therapy (LDT) for those with