Janssen Presents New Data for Talquetamab, a First-in-Class GPRC5DxCD3 Bispecific Antibody, Suggesting Durable Responses in Patients with Heavily Pretreated Multiple Myeloma

NEW ORLEANS, December 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today updated results from the Phase 1/2 MonumenTAL-1 study of talquetamab, an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody. Talquetamab targets both GPRC5D, a novel target on multiple myeloma cells, and CD3 on T cells, activating the body’s immune system to fight this blood cancer.[1] Results from the study suggest patients with relapsed or refractory multiple myeloma who received a median of five prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 antibody, achieved overall response rates (ORR) of 74.1 percent and 73.1 percent with subcutaneously (SC) administered recommended Phase 2 doses (RP2Ds) of 0.4 mg/kg weekly and 0.8 mg/kg every two weeks, respectively, with a median duration of response (DOR) of nine months or longer.[2] Data from this investigational trial were featured during the American Society of Hematology (ASH) Annual Meeting as an oral presentation and highlighted in an ASH press briefing on Saturday, December 10, 2022 (Abstract #157).[2]  “The responses observed in the MonumenTAL-1 study suggest the clinical potential of talquetamab in the treatment of many patients who are triple-class refractory,” said Ajai Chari, M.D., Professor of Medicine, Hematology and Medical Oncology, Icahn School of Medicine, Mount Sinai, and principal study investigator.†&nbs...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Latest News Source Type: news