Learning from healthy and stable eyes: a new approach for detection of glaucomatous progression

Conclusion: The use of the dependency measurement in the SVDD framework increased the robustness of the proposed change-detection scheme with comparison to the classical support vector machine and SVDD methods. The validation using clinical data of the proposed approach has shown that the use of only healthy and non-progressing eyes to train the algorithm led to a high diagnostic accuracy for detecting glaucoma progression compared to other methods.
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research

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This study is aimed to investigate the effects of periocular steroids induction on intraocular pressure (IOP), retinal ganglion cells (RGCs) and trabecular meshwork (TM) ultrastructure in glucocorticoid-induced ocular hypertension mice model. Materials and Methods: Dexamethasone-21-acetate (Dex-Ace) was administered through periocular conjunctival fornix injection every 3 days in C57BL/6J mice. Intraocular pressure was measured weekly by rebound tonometry. RGCs were examined with immunofluorescent staining of BRN3a at week 1, 4, and 8. TM morphology was visualized with electron microscopy. Autophagy was evaluated with immu...
Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
Abstract Endoplasmic reticulum (ER) stress is recognized as a contributing factor to various ocular neurovascular pathologies including retinitis pigmentosa, glaucoma, and diabetic retinopathy (DR). ER stress in particular is implicated in the development of DR, which is significantly influenced by inflammation driven retinal vascular degeneration and dysfunction. Ultimately, loss of vision occurs if left untreated. However, the identity of the target cells and their temporal involvement in diabetes-mediated dysfunction need further investigation. Early diabetes-induced stress in photoreceptor cells is proposed as...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
In conclusion, with study of the frailty syndrome still in its infancy, frailty analysis remains a major challenge. It is a challenge that needs to be overcome in order to shed light on the multiple mechanisms involved in the pathogenesis of this syndrome. Although several mechanisms contribute to frailty, immune system alteration seems to play a central role: this syndrome is characterized by increased levels of pro-inflammatory markers and the resulting pro-inflammatory status can have negative effects on various organs. Future studies should aim to better clarify the immune system alteration in frailty, and seek to esta...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
It has for some years now been possible to reprogram adult somatic cells into pluripotent stem cells that are functionally equivalent to embryonic stem cells. This is achieved by overexpressing some or all of the Yamanaka transcription factors, Oct4, Sox2, Klf4, and c-Myc (OSKM) proteins. One of the most interesting outcomes of this process is that cells so treated reverse epigenetic markers of aging to some degree, and repair their mitochondrial damage. Thus the research community has started to induce this same reprogramming in living animals to observe the results. If done haphazardly, the outcome is unrestrained cancer...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Discussion: Mean, superior, inferonasal, superonasal, and superotemporal GC-IPL thicknesses and mean c/d ratio, vertical c/d ratio and cup volume were found to be correlated with BCVA in patients with severe glaucoma. PMID: 31361521 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
This article is protected by copyright. All rights reserved. PMID: 31330064 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
Publication date: Available online 10 July 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Stephanie B. Syc-Mazurek, Richard T. LibbyAbstractAxonal degeneration is an active, highly controlled process that contributes to beneficial processes, such as developmental pruning, but also to neurodegeneration. In glaucoma, ocular hypertension leads to vision loss by killing the output neurons of the retina, the retinal ganglion cells (RGC). Multiple processes have been proposed to contribute to and/or mediate axonal injury in glaucoma including: neuroinflammation, loss of neurotropic factors, dysregulation of the neuro...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Authors: Yu L, Yang J Abstract PMID: 31262145 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
This study goes beyond the regulation of individual gene expression showing striking changes in the control of expression by Complement cascade and Notch signaling functional pathways important for RGC degeneration and remodeling of the retinal tissue two weeks after O NC.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
We report the development of an RGC cell model, XFC-3 cells, as a tool for preclinical screening of three non-viral gene delivery systems (made from dicationic gemini surfactants, single-walled carbon nanotubes, and K2-lipopolyamine polymers) for glaucoma neurotrophic factor gene therapy. XFC-3 cells were isolated from differentiated MRSCs and characterized by gene expression profiling and neurite extension activity. XFC-3 cells also demonstrated effectiveness and versatility in 3D co-culture bioassay models for therapeutic protein bioactivity assessment.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
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