AutomiRDB: a web resource connecting microRNAs and autophagy in cancer

Source: Apoptosis - Category: Molecular Biology Source Type: research

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Publication date: Available online 26 May 2020Source: Molecular and Cellular ProbesAuthor(s): Jieping Hu, Jun Deng, Runfu Cao, Shida Xiong, Ju Guo
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: Available online 27 May 2020Source: Life SciencesAuthor(s): Mengwei Wu, Xiaodong Tan, Peng Liu, Yifan Yang, Yinpeng Huang, Xinlu Liu, Xiangli Meng, Boqiang Yu, Yunhao Wu, Haoyi Jin
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 26 May 2020Source: Life SciencesAuthor(s): Delu Dong, Yuan Dong, Jiaying Fu, Shengyao Lu, Chunli Yuan, Meihui Xia, Liankun Sun
Source: Life Sciences - Category: Biology Source Type: research
Autophagy is a well-maintained process by which the cells recycle intracellular materials to maintain homeostasis in various cellular functions. However, autophagy is a defensive mechanism that maintains cell survival under antagonistic conditions, the induction of the autophagic process may substantially lead to cell death. The conflicting roles of autophagy including allowing cell survival or promoting cell death could have a troublesome impact on the efficiency of chemotherapeutic agents. Accordingly, understanding the role of autophagy in cancer is a vital need for its optimal manipulation in therapy.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research
In human cells, Heat Shock Protein-90 (HSP-90) is present in the cytosol, nucleoplasm, endoplasmic reticulum, and mitochondria. The eukaryotic HSP-90 is multifunctionary and essential for cell viability, signal transduction, cell-cycle control as well as transcriptional regulation. The intracellular environment does not restrict HSP-90. It has a vital role in all types of inflammatory disorders, including cancer, autoimmune diseases, infectious inflammatory conditions. Hence, pharmacological inhibition of HSP-90 is currently a choice of therapeutic target for the treatment of autoimmune diseases, cancer, and infectious dis...
Source: Current Chemical Biology - Category: Biochemistry Source Type: research
Conclusion: In vitro biological evaluations revealed that dimethoxy and trimethoxy indanonic spiroisoxazoline compounds are good candidates for the development of new anti-liver cancer agents.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research
Conclusion: This study signifies the clear differences in DNA metabolizing effects of goat UDF over other selected animal sources. Furthermore, the observed DNA metabolizing effects of goat UDF well correlate with anti-proliferative effects upon HCT-116 and MCF-7 cells. This study is a first report to show the comparison of urine metabolites among various animals. Interestingly, findings propose an indirect link that may support the possible reasons behind xeno-tumor heterogeneity in the form of rare occurrences of colorectal and mammary cancer in goat over other ruminants, non-ruminants and human.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research
Publication date: Available online 26 May 2020Source: Chinese Chemical LettersAuthor(s): Mengxue He, Ling Yu, Yuanyuan Yang, Binhua Zou, Wen Ma, Meng Yu, Jiandong Lu, Guoliang Xiong, Zhiqiang Yu, Aimin Li
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Dalton Trans., 2020, Advance Article DOI: 10.1039/D0DT00845A, PaperLily Li, Hsiou-Ting Kuo, Xiaozhu Wang, Helen Merkens, Nadine Colpo, Valery Radchenko, Paul Schaffer, Kuo-Shyan Lin, Fran çois Bénard, Chris Orvig A new bifunctionaltBu4octapa-alkyl-NHS was synthesized for metalloradiopeptide preparation; proof-of-principle prostate-cancer targeting with lutetium-177 was demonstrated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence. Satrialdi, Reina Munechika, Vasudevanpillai Biju, Yuta Takano, Hideyoshi Harashima, Yuma Yamada To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
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