Neuroinflammation-Related Proteins NOD2 and Spp1 Are Abnormally Upregulated in Amyotrophic Lateral Sclerosis

Discussion Our discovery-based approach identified NOD2 as a novel biomarker in ALS and adds evidence to the contribution of Spp1 in the disease process. Both proteins are involved in innate immunity and autophagy and are increased in the serum from patients with ALS. Our data support a relevant role of neuroinflammation in the pathophysiology of the disease and may identify targets for disease-modifying treatments in ALS. Further longitudinal studies should investigate the diagnostic and prognostic value of NOD2 and Spp1 in clinical practice.

http://nn.neurology.org/cgi/content/short/10/2/e200072?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - December 2, 2022 Category: Neurology Authors: de Luna, N., Carbayo, A., Dols-Icardo, O., Turon-Sans, J., Reyes-Leiva, D., Illan-Gala, I., Jerico, I., Pagola-Lorz, I., Lleixa, C., Querol, L., Rubio-Guerra, S., Alcolea, D., Fortea, J., Lleo, A., Cortes-Vicente, E., Rojas-Garcia, R. Tags: Research Article Source Type: research