Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders

Conclusions: The observed relaxant effect may be outcome of anti-muscarinic and Ca2+ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and K+(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through Ca2+ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system.
Source: Journal of Translational Medicine - Category: Research Authors: Source Type: research