Effects of high progesterone on outcomes of in vitro fertilization-embryo transfer in patients with different ovarian responses.

Effects of high progesterone on outcomes of in vitro fertilization-embryo transfer in patients with different ovarian responses. Syst Biol Reprod Med. 2015 Apr 27;:1-7 Authors: Li PF, Zhu H, Tan L, Zhao DM, Ma LY, Xiang YG, Zhang D, Dou Q, Lu N Abstract The data of 3,841 cycles undergoing in vitro fertilization-embryo transfer (IVF-ET) in our reproductive Center between January 2003 and December 2013 were retrospectively analyzed. According to the number of oocytes retrieved, this study was divided into the high ovarian response group (oocyte retrieval ≥20, 842 cycles), the moderate ovarian response group (5< oocyte retrieval <20, 2008 cycles), and the low ovarian response group (oocyte retrieval ≤5, 991 cycles). The treatment outcomes were compared between the patients with an increased progesterone (P) level and the patients where the P level did not increase. With increase in ovarian response, the cut-off values of serum P on the day of human chorionic gonadotrophin (hCG) rose, and respectively were 2.5 ng/ml in the high ovarian response group, 2.25 ng/ml in the moderate ovarian response group, and 1.5 ng/ml in the low ovarian response group. In each group, the clinical pregnancy rate and embryo implantation rate were lower in the patients with an increased P level compared to those where the P level did not increase (all p < 0.05). However, there were no significant difference in the fertilization rate, cle...
Source: Systems Biology in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research