[18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a pilot study
CONCLUSIONS: The decline in [18F]FTT uptake shortly after PARPi initiation provides a measure of drug-target engagement and shows promise as a biomarker to guide PARPi therapies in this pilot study. These results support additional pre-clinical mechanistic and clinical studies in subjects receiving PARPi +/- combination therapy.PMID:36441795 | DOI:10.1158/1078-0432.CCR-22-1602
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Austin R Pantel Sarah B Gitto Mehran Makvandi Hyoung Kim Sergey Medvedv Joanna K Weeks Drew A Torigian Chia-Ju Hsieh Benjamin Ferman Nawar A Latif Janos L Tanyi Lainie P Martin Shannon M Lanzo Fang Liu Quy Cao Gordon B Mills Robert K Doot David A Mankoff Source Type: research