Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats [Basic Sciences]

Conclusions—
Dissociating N-methyl-d-aspartate receptor–postsynaptic density protein-95 coupling by Tat-HA-NR2B9c in the subacute phase after stroke promotes functional recovery, probably because of that it increases neurogenesis and dendritic spine density of mature neurons via regulating cyclin-dependent kinase 5 in the ischemic brain.

Source: Stroke - April 27, 2015 Category: Neurology Authors: Zhou, H.-H., Tang, Y., Zhang, X.-Y., Luo, C.-X., Gao, L.-Y., Wu, H.-Y., Chang, L., Zhu, D.-Y. Tags: Animal models of human disease, Neuroprotectors Basic Sciences Source Type: research