021 IL-4 Receptor α Blockade Attenuates Allergic Conjunctivitis in a Novel Murine Ocular Model

Conjunctivitis, a common comorbidity in atopic dermatitis (AD), occurs at an increased frequency in AD patients given treatments that target interleukin-4 receptor alpha (IL-4R α) or IL-13. However, the mechanisms driving this development of conjunctivitis remain unknown for AD. Wild-type BALB/c mice were treated epicutaneously with MC903 (calcipotriol)+ ovalbumin (OVA) to evoke AD-like disease and challenged ocularly with OVA or with vehicle control (phosphate-buffered s aline [PBS]) once daily for 7 days.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research