378 Ultraviolet radiation-induced antimicrobials neutralize S. aureus and reduce atopic dermatitis-associated inflammation

Atopic dermatitis (AD) is a common inflammatory skin disease with increased colonization by pathogenic Staphylococcus aureus, which has been linked to production of abnormal levels of antimicrobial peptides (AMPs) in AD skin. Ultraviolet radiation (UVR) phototherapy is a widely used treatment for AD. We hypothesize that the efficacy of phototherapy in AD patients depends on the ability of UVR to (re)induce the expression of AMPs from host skin and normalize dysbiotic S. aureus colonization. To test this hypothesis, we developed a new mouse model of AD by treating the skin with calcipotriol (MC903) and an S.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research