Longitudinal Postvaccine SARS-CoV-2 Immunoglobulin G Titers, Memory B-Cell Responses, and Risk of COVID-19 in Multiple Sclerosis Over 1 Year

Discussion
Postvaccine anti-S IgG titers decrease over time regardless of MS treatment and are associated with breakthrough COVID-19. Both humoral and specific memory B-cell responses are diminished on S1P modulators. Within anti-CD20–treated patients, B-cell count at first vaccine determines anti-S IgG production, whereas postvaccine anti-CD20 infusions negatively affect spike-specific memory B cells.

Source: Neurology Neuroimmunology and Neuroinflammation - November 17, 2022 Category: Neurology Authors: Disanto, G., Galante, A., Cantu', M., Sacco, R., Mele, F., Eisler, J. J., Keller, F., Bernasconi, E., Sallusto, F., Zecca, C., Gobbi, C. Tags: Research Article Source Type: research